These Derm-Approved Wrinkle Fillers Will Actually Help Plump Skin (2025)

This wrinkle-filling serum from RoC was named a favorite by both Dr. Garhsick and Dr. Zeichner for its advanced formulation. “It combines hyaluronic acid for immediate plumping along with a stabilized form of retinol to stimulate collagen and strengthen the skin with continued use,” Dr. Zeichner explains.

What a reviewer says: “I’m a skeptic and often critical about over-hyped products, but I have been pleasantly surprised with this one! After gaining a bunch of weight, post illness, I had necklines that I was very uncomfortable with. This plumped them up and has made a big long term difference! My guess? Be prepared to set up subscribe and save!”

According to the pros, hyaluronic acid is a key ingredient to look for in wrinkle fillers (there’s a reason it’s the main ingredient in in-office dermal fillers!). “This serum delivers two forms of hyaluronic acid, both low and high molecular weight to hydrate, smooth, and fill the skin both deep in the skin and at the surface,” Dr. Zeichner explains.

What a reviewer says: “I was excited to try a serum as someone who is always looking for the fountain of youth for anti-aging. Hyaluronic acid is one of the most important ingredients in my opinion for dulling fine lines and wrinkles. This serum has a light, clean scent that I enjoyed. The gel is thick enough that it applies evenly and absorbs quickly. I found my skin to be surprisingly soft after using. In fact, I didn’t necessarily even need a moisturizer and will often use it on its own after cleansing. This may be one of the most impactful serums I’ve used!”

If you’re not quite ready to experiment with or invest in botox, Mraz suggests this derm-approved eye cream treatment from Skin Better Science. “The skin around our eyes is unique, so seeking a targeted product for this area is important. The skin around the eyes is thinner and naturally has less collagen and sebaceous glands,” explains Mraz. “[For crow’s feet] I really like Skinbetter Science's Interfuse Eyes. While nothing can replace the ‘real deal’ when it comes to toxin, this formula includes niacinamide and caffeine which help depuff and smooth the skin.”

What a reviewer says: “I absolutely adore this eye cream from SkinBetter Science. It’s incredibly nourishing and addresses everything—dark circles, dryness, puffiness, and fine lines. It’s one of the best eye creams I’ve used in a long time.”

Retinol is a great anti-aging ingredient because it “increases the rate at which dead skin cells are shed and new ones are created,” explains. “I really like chemical exfoliation that doesn’t cause excessive dryness, because it tends to be something patients can tolerate better and will therefore use more consistently” she adds. Dr. Engleman agrees and recommends this hydrating formula which also contains peptides, hyaluronic acid, and ceramides to help provide “smooth, glowing skin without irritation,” he explained.

What a reviewer says: “I’ve been using it for about six months and it has been the only product to improve my hormonal acne. It also lessened the fine lines on my forehead and eye area! I was genuinely considering fillers, but I don't think I need them anymore.”

If you are looking to help reduce your laugh lines, Mraz has this science-backed recommendation. “The areas of our face that move the most can be the most prone to static wrinkles, therefore the mouth can be particularly tricky!” she says. “Neova SmartSkincare Power Defense is an advanced serum formulated with Copper Peptide Complex antioxidants,” she continues. This infusion of hydration helps improve and strengthen your skin’s barrier, as well as protect it from additional harm—meaning it can help reduce your current laugh lines, while also preventing future creasing.

What a reviewer says: “I have been using the Power Defense serum for a long time. My skin just keeps getting better and better with the minimization of fine lines and healthy looking skin. Love this stuff!!”

“This twice-daily serum contains a blend of peptides (including copper peptides), ceramides, niacinamide, and hyaluronic acid to improve the overall appearance of fine lines and wrinkles while also strengthening the skin’s moisture barrier,” explains Dr. Garshick. Plus, some reviewers even report that using this serum negates their desire for Botox and filler.

What a reviewer says: “As a professional makeup artist, I can’t recommend this serum enough! It plumps fine lines and delivers a hydrated, youthful glow. Perfect under makeup—my clients are always amazed at the difference it makes.”

This serum delivers heaps of skin-loving ingredients to your skin, including hyaluronic acid—which Dr. Zeichner says “fills and plumps” as well as peptides to help “strengthen the skin.” It also contains other powerful humectants, like glycerin and polyglutamic acid, for hydrating and plumping the skin.

What a reviewer says: “I have been using this product for three months. It took about three weeks for me to se a difference but after, my skin is visibly plumper, smoother, and I’ve had several complements from friends about how good my skin looks. I do use the supplement’s 360 Youth Bomb also. I would highly recommend this product . I’m 54 years young!”

If you’re looking for instant results or a “quick fix,” Dr. Garshick recommends this serum from No 7. “This at-home treatment uses glycerin and light-diffusing particles, which blurs the appearance of fine lines and wrinkles without irritating the skin,” she explains.

What a reviewer says: “I got this to use for my wedding. So happy with the results—as you can see how I look at age 70. It’s important to know this is a line filler and not a wrinkle tightener for under eye. I used it mainly for lines between nose and mouth. Around my upper lip. A great price for an effective product. I have purchased the more expensive ones, and I think this worked even better.”

This cream, as opposed to a serum, helps fill in wrinkles by plumping and hydrating the skin and was previously named one of the best anti-aging creams by Dr. Jaliman. The cream contains hyaluronic acid to plump and hydrate, amino peptides to firm the skin, as well as niacinamide to brighten the complexion.

What a reviewer says: “I’ve been using this face cream for about four years and I love it! It keeps my skin hydrated, it doesn’t seem to clog my pores, and I swear it has kept the wrinkles at bay,” wrote one Amazon shopper. “I’m in my mid-40s and people always tell me I look younger. In fact, I really don’t have any wrinkles at all and I think this cream has helped with that!”

Formulated with peptides, hyaluronic acid, niacinamide, and ectoin, this serum helps to “fill lines” and “boost moisture and volume” says Dr. Garshick. The serum is formulated to provide immediate and long-term results with a variety of ingredients designed to deeply hydrate the skin while boosting collagen production with continued use.

What a reviewer says: “I’m impressed with how lightweight this moisturizing lotion is. It goes on smoothly and gets absorbed by the skin in no time. It’s great for sensitive skin and a great choice for moisturizing my face. Since I’ve been using it regularly for a few weeks now, I’ve noticed a remarkable difference in how smooth and healthy my skin looks and feels. I couldn’t be happier with the results.”

Dr. Zeichner recommends this “multitasking” not only for its ability to “hydrate, plump, and minimize the appearance of lines” with hyaluronic acid but also for its ability to protect the skin from UV rays and environmental aggressors. “Plus it forms a smooth canvas for makeup,” he adds.

What a reviewer says: “The primer is a creamy color with a beautiful sheen, and looks incredible on its own for a bare faced look. Under foundation, it seems to smooth over any enlarged pores, and doesn’t allow the foundation to cling to dry skin making it ideal for the winter months. I usually struggle to find a primer that allows my foundation to stay put, and I thought the SPF would give me issues, but to my surprise, my skin stayed flawless, with a beautiful fresh dewy look all day.”

“This serum combines heirloom apple and grape stem cells which are rich in antioxidants, coenzyme Q10 which also helps to smooth the skin, and goji glycopeptides which help to firm and lift the skin,” explains Dr. Garshick. “It helps hydrate and smooth the skin, improving the appearance of fine lines and wrinkles.”

What a reviewer says: “I am VERY pleased with how well it works. I used it on my ‘kissy wrinkles’ around my lips and I could hardly believe the results! I like the way it seems to hydrate my skin, as well as filling in the lines around my mouth.

“Combining peptides, pomegranate seed oil, and hyaluronic acid, this serum works to improve the appearance of fine lines and wrinkles while also helping to firm, lift, and tighten the skin,” says Dr. Garshick, who adds that it is “especially good for those with mature skin” due to it’s gentle, hydrating formula.

What a reviewer says: “This serum is outrageously good! I saw my fine lines substantially diminished after just a few days of use, and my entire face feels soft, dewy, and super firm.”

Dr. Garshick recommends this formula from Revision Skincare for its ability to “reduce the appearance of expression lines” with a patent-pending blend of peptides as well as “plump the skin” and reduce dryness with hyaluronic acid. “It can be used twice daily and should be massaged into any area of fine lines and wrinkles,” Dr. Garshick adds.

What a reviewer says: “I am 58 years old and stopped using Botox five years ago. Since stopping, I have had a lot of deep wrinkles around my eyes and forehead. I was reluctant to invest a lot of money on a product like this, but I am seeing some dramatic results. Yes, the wrinkles are still there, but the creases are much smaller, finer, and I think are suitable for a woman my age.”

While at-home (topical) products can certainly do wonders in improving the appearance of wrinkles, “the effect is generally considered temporary,” Dr. Garshick explains. However, certain ingredients that have been shown to boost collagen production (like retinol and peptides) may be beneficial in improving the appearance of wrinkles long-term, she adds.

“When used regularly, topical wrinkle serums can be effective at improving wrinkles and preventing new ones,” Dr. Mraz agrees. “However they can be most effective when paired with treatments such as lasers and injectable neuromodulators.” A.K.A., don’t expect your at-home creams and serums to have the same level of effectiveness as in-office treatments.

Dr. Garshick suggests looking for the following ingredients in at-home wrinkle fillers:

✔️ Hyaluronic acid. Products containing hyaluronic acid help “to draw moisture in and works to plump the skin,” Dr. Garshick says.

✔️ Retinol. Retinol has been proven to prevent and address visible signs of aging, including fine lines and wrinkles, for its ability to regulate skin cell turnover and boost collagen production.

✔️ Peptides. Like retinol, peptides help boost collagen, per Dr. Garshick. In doing so, peptide serums and creams can help plump the skin and reduce the appearance of fine lines and wrinkles.

When it comes to using wrinkle fillers, it’s always best to follow the directions on the packaging and consult your dermatologist if you have any questions or concerns.